L a r g e G r a n u l a t e d L y m p h o c y t e L e u k e m i a
General
• Large granulated lymphocyte leukemia is a rare, lymphoproliferative disorder
of T cells which are large and display cytoplasmic granules.
• Two types: cytotoxic and natural killer (NK) cell.
Clinical Features
• Usually occurs in late middle age.
• Symptoms mostly related to severe neutropenia (recurrent infections are
common).
• Long survival.
Morphology
Blood
• Proliferation of large lymphocytes with abundant, clear cytoplasm and 
cytoplasmic granules (may look like Downey II lymphocytes).
Bone marrow
• Same as blood.
Laboratory Findings
• Modest increase in WBC.
• Neutropenia - may be severe.
