P r o l y m p h o c y t i c L e u k e m i a
General
• Prolymphocytic leukemia is a rare chronic lymphoproliferative disorder in
which the predominant cell is the prolymphocyte.
• Most cases of PL are of B-cell type, but a minority are of T-cell type.
Clinical Features
• Older patients.
• Marked splenomegaly without lymphadenopathy.
• More aggressive than other chronic lymphoproliferative disorders.
Morphology
Blood
• Proliferation of lymphocytes, over half of which are prolymphocytes.
• Prolymphocytes are large cells with coarse chromatin and a single,
prominent nucleolus.
Bone marrow
• Same as blood.
Laboratory Findings
• WBC increased
• Hgb decreased
• Platelets decreased
