A d u l t T - C e l l L e u k e m i a / L y m p h o m a
Morphology
• Big lymphocytes with flowery nuclei
• Also a few smaller, less showy lymphocytes
Immunophenotype
T-cell.
Clinical features
• Endemic in Japan and Caribbean basin, but seen in US too (especially
southeastern states).
• Associated with HTLV-1 infection.
• Skin lesions, lymphadenopathy, hepatosplenomegaly, hypercalcemia.
• Very aggressive (mean survival = 8 months).
