R E A L C l a s s i f i c a t i o n
The REAL (Revised European-American) Classification of Lymphoid Neoplasms
was put together by a group of hematopathologists in 1994. This is the classification upon which the current WHO (World Health Organization) classification was built (not much changed, really!). Don't memorize this REAL classification - it's just put here for your perusal, since you will undoubtedly run across a reference to it at some point.
B-cell neoplasms
• Precursor B-cell neoplasm
• Precursor B-lymphoblastic leukemia/lymphoma
• Peripheral B-cell neoplasms:
• B-cell CLL/SLL
• Lymphoplasmacytic lymphoma
• Mantle cell lymphoma
• Follicle center lymphoma
• grade I (small cell)
• grade II (mixed)
• grade III (large cell)
• Marginal zone lymphoma
• Splenic marginal zone lymphoma
• Hairy cell leukemia
• Plasma cell myeloma (multiple myeloma)
• Diffuse large B-cell lymphoma
• Burkitt's lymphoma
T- and NK-cell neoplasms
• Precursor T-cell neoplasm
• Precursor T-lymphoblastic leukemia/lymphoma
• Peripheral T-cell and NK-cell neoplasms:
• T-cell CLL
• Large granular lymphocyte leukemia
• Mycosis fungoides/Sézary syndrome
• Peripheral T-cell lymphoma
• Adult T-cell leukemia/lymphoma
• Anaplastic large cell lymphoma
Hodgkin Disease
• Lymphocyte predominance Hodgkin Disease
• Classical Hodgkin disease
• Nodular sclerosis
• Mixed cellularity
• Lymphocyte depletion
• Lymphocyte-rich classical Hodgkin's disease
