W o r k i n g F o r m u l a t i o n
Put together by a bunch of hematopathologists in 1982, in a feeble attempt to stave off angry (rightly so!) clinicians. There were all kinds lymphoma classifications around by now ("Rappaport", “Lukes and Collins”, “Kiel”, others) and the clinicians didn’t care whether the cells were small and round or large and pointy; they just wanted to know whether it was a bad lymphoma or a not-so-bad lymphoma. So the hematopathologists lumped all the known lymphomas into three groups: low-grade (not-so-bad), intermediate grade (also not-so-bad), and high-grade (bad) lymphomas.
Low-Grade Lymphomas
Small lymphocytic lymphoma
Follicular small cleaved cell lymphoma
Follicular mixed small cleaved and large cell lymphoma
Intermediate-Grade Lymphomas
Follicular large cell lymphoma
Diffuse small cleaved cell lymphoma
Diffuse mixed small and large cell lymphoma
Diffuse large cell lymphoma
High-Grade Lymphomas
Large cell immunoblastic lymphoma
Lymphoblastic lymphoma
Small non-cleaved cell (Burkitt’s) lymphoma
