M a n t l e C e l l L y m p h o m a
Morphology
• Pattern: follicular pattern with expanded mantle zones (early), or diffuse
pattern (later on).
• Cytology: composed of small, angulated lymphocytes (like those in mantle
zones of normal, benign follicles).
Immunophenotype
B-cell.
Translocation
• t(11;14).
• Involves bcl-1 gene (on chromosome 11) and immunoglobulin heavy chain
gene (on chromosome 14).
Clinical features
• Resistant to therapy.
• Mean survival = 4 years.
