M y c o s i s F u n g o i d e s / S é z a r y S y n d r o m e
Clinical features
• Mycosis fungoides (Latin: “toadstools! toadstools!”): Cutaneous lesions (filled
with lymphoma cells) evolve from inflammatory stage (flat, red) through
plaque stage (slightly raised) to tumor stage (big bumps). Usually no blood
involvement.
• Sézary syndrome: Cutaneous lesions do not progress past plaque stage;
tumor cells often spill into blood.
Morphology
• Skin: Pautrier "microabscesses" (collections of tumor cells)
• Characteristic "cerebriform" lymphoma cells with very convoluted nuclei.
Immunophenotype
T-cell.
