T e s t s : C h r o n i c L y m p h o c y t i c L e u k e m i a
Note: more questions will be added, so please check back from to time.
Answers are posted on a separate answer page, which you may want to look at after you've done all the questions, so you don't accidentally see answers to questions you haven't done yet!
Question 1
Match each lymphoid disorder with its immunophenotype.
1.
Chronic lymphocytic leukemia
2.Precursor B-cell acute lymphoblastic leukemia
3.B-cell acute lymphoblastic leukemia
4.T-cell acute lymphoblastic leukemia
TdT Surface Ig CD2 CD5 CD19
b. - + - + +
c. + - - - +
d. + - + + -
Question 2
Which of the following chronic lymphoproliferative disorders presents with splenomegaly but no lymphadenopathy?
a.Hairy cell leukemia
b.Chronic lymphocytic leukemia
c.Prolymphocytic leukemia
d.a and c
e.a, b and c
Question 3
A 57 year-old male presents with several months of fatigue. A blood smear shows the following data:
WBC 3.8 x 10 /L (4 -11)Hemoglobin9.0 g/dL (12-16)
Differential: neutrophils 36% Platelet count 125,000 x 10 /L
lymphocytes 60% (150,000-450,000)
monocytes 0%
basophils 1%
eosinophils 3%
A bone marrow biopsy shows a "moth-eaten" bone marrow, with a population of lymphocytes with shaggy, fluffy cytoplasm.
The cytochemical stain most useful in diagnosing this disorder is:
a.Sudan black B (SBB)
b.Non-specific esterase (NSE)
c.Chloroacetate esterase (CAE)
d.Tartrate-resistant acid phosphatase (TRAP)
e.Myeloperoxidase (MPO)
